This study has being conducted in Southern Israel and is aimed to estimate the association between ambient air temperature and cardiovascular outcomes at an individual level. Temperature exposure will be evaluated in terms of mean and extreme temperature exposure and in terms of variability of exposure to temperature during specific time-windows. We will assess the incidence of acute coronary syndrome, ischemic stroke and cardiac death. We will investigate the effects of various (short- and long-term) time-windows of temperature exposure.